Title of article :
Influence of low methoxyl pectin gel textures and in vitro release of rutin from calcium pectinate beads
Author/Authors :
Jantrawut، نويسنده , , Pensak and Assifaoui، نويسنده , , Ali and Chambin، نويسنده , , Odile، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Pages :
8
From page :
335
To page :
342
Abstract :
This study described the preparation and characterization of low methoxyl pectin (LMP) gels and beads for controlled release applications. The rheological characterization of the various formulations was proposed. Then the mechanical and morphological characterizations of beads were determined. Finally, the controlled release studies taking rutin as a model drug was evaluated. The results showed that Youngʹs modulus values of non-amidated LMP gels decrease when adding up to 15% sorbitol. Calcium pectinate beads loaded with rutin are about 600 μm, oblong shaped with dense matrix. Beads containing sodium bicarbonate showed about 80% lower rutin encapsulation efficiency by increasing the pH of the cross-linking solution. The rutin loaded in non-amidated pectinate beads containing 15% sorbitol showed the best release efficiency and swelling behavior. Therefore, the gel texture affects the release rate of the active compounds encapsulated in calcium pectinate beads and can be used as a parameter to modulate drug release.
Keywords :
Texture analysis , Rutin , In vitro release , Low methoxyl pectin
Journal title :
CARBOHYDRATE POLYMERS
Serial Year :
2013
Journal title :
CARBOHYDRATE POLYMERS
Record number :
1624918
Link To Document :
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