Preparation and characterization of inclusion complexes of naringenin with β-cyclodextrin or its derivative

The inclusion complexation behavior, characterization and binding ability of naringenin with β-cyclodextrin and its derivatives were investigated in both solution and the solid state by means of XRD, DSC, SEM, 1H and 2D NMR and UV–vis spectroscopy. The results showed that the water solubility and thermal stability of naringenin were obviously increased in the inclusion complex with cyclodextrins. This satisfactory water solubility and high thermal stability of the naringenin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products.