Author/Authors :
Xiao، نويسنده , , Chuan-Fan and Li، نويسنده , , Ke and Huang، نويسنده , , Rong and He، نويسنده , , Guo-Jin and Zhang، نويسنده , , Jian-Qiang and Zhu، نويسنده , , Li and Yang، نويسنده , , Qing-Yi and Jiang، نويسنده , , Kun-Ming and Jin، نويسنده , , Yi and Lin، نويسنده , , Jun، نويسنده ,
Abstract :
The inclusion complexation of Epothilone A with native cyclodextrin (β- or γ-CD) and its derivative hydroxypropyl-β-cyclodextrin (HPβCD) were prepared. Their behavior, characterization, and binding ability were investigated in both solution and the solid state by means of UV–vis, NMR, XRD, DSC and SEM. The results show that the water solubility and solution stability obviously increased in the inclusion complex with cyclodextrins. Meanwhile, the inclusion complexes still retained anticancer activity against A549 and MCF-7 cells, similar to free Epothilone A. This satisfactory water solubility, high solution stability, and high anticancer activity of the Epothilone A/CD complexes will be potentially useful as an anticancer therapy.
Keywords :
cyclodextrin , Inclusion mode , characterization , Inclusion complex , Epothilone A
