Preparation, characterization and pulmonary pharmacokinetics of xyloglucan microspheres as dry powder inhalation

The purpose of the present investigation was to prepare microspheres using xyloglucan as the polymer and to evaluate them for pulmonary delivery of Montelucast. Xyloglucan microspheres were prepared using spray-drying technique employing lactose monohydrate as carrier for dry powder inhalation. The formulation of microspheres was optimized using response surface methodology. Multiple response surface simultaneous optimizations using desirability approach were use to find optimal formulation. In vitro characterization of optimized microsphere formulation demonstrates its suitability as dry powder inhalation. It found to provide high and prolonged drug concentration within lungs after pulmonary administration in animal model.