Title of article :
Modification of agarose: 6-Aminoagarose mediated syntheses of fluorogenic pyridine carboxylic acid amides
Author/Authors :
Sandeep K. Kondaveeti، نويسنده , , Stalin and Mehta، نويسنده , , Gaurav K. and Siddhanta، نويسنده , , A.K.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Pages :
9
From page :
365
To page :
373
Abstract :
A facile 6-aminoagarose (AA) mediated synthesis of new fluorogenic amides of agarose with nicotinic (AA-NA) and picolinic acids (AA-PA) employing carbodiimide chemistry have been described. 6-Amino agarose (AA) was synthesized in a facile Mitsunobu-inspired microwave mediated method involving the reaction of agarose with phthalimide in presence of diisopropyl azodicarboxylate and triphenylphosphene (DIAD/TPP) followed by hydrazinolysis. All compounds were characterized by GPC, UV spectrophotometry, fluorescence spectroscopy, FT-IR, 1H and 13C NMR spectra. The fluorescence emissions (λmax 430 and 412 nm) of 1 × 10−3 M solutions of AA-NA and AA-PA in water were significantly higher (ca. 82% and ca. 90%) than those of the molar equivalents (0.2 mg) of NA and PA present in the 1 × 10−3 M solutions of the amides, respectively. These fluorogenic pyridine carboxylic acid amides of agarose may find applications as sensors in biomedical and pharmaceutical industries.
Keywords :
amide , Aminoagarose , fluorescence , Picolinic acid , Hydrogel , Nicotinic acid
Journal title :
CARBOHYDRATE POLYMERS
Serial Year :
2014
Journal title :
CARBOHYDRATE POLYMERS
Record number :
1626305
Link To Document :
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