Title of article
Photoactive spatial proximity probes for binding pairs with epigenetic marks
Author/Authors
Ezhov، نويسنده , , Roman N. and Metzel، نويسنده , , Greg A. and Mukhina، نويسنده , , Olga A. and Musselman، نويسنده , , Catherine A. and Kutateladze، نويسنده , , Tatiana G. and Gustafson، نويسنده , , Tiffany P. and Kutateladze، نويسنده , , Andrei G.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
8
From page
101
To page
108
Abstract
A new strategy for encoding polypeptide libraries with photolabile tags is developed. The photoassisted assay, based on conditional release of encoding tags only from bound pairs, can differentiate between peptides which have minor differences in a form of post-translational modifications with epigenetic marks. The encoding strategy is fully compatible with automated peptide synthesis. The encoding pendants are compact and do not perturb potential binding interactions.
Keywords
Encoded combinatorial library , Spatial proximity test , Conditional photorelease of tags , epigenetic marks
Journal title
Journal of Photochemistry and Photobiology:A:Chemistry
Serial Year
2014
Journal title
Journal of Photochemistry and Photobiology:A:Chemistry
Record number
1628455
Link To Document