Author/Authors :
Hou، نويسنده , , Yongchun and Xie، نويسنده , , Wenhua and Ramachandran، نويسنده , , Niroshan and Mutus، نويسنده , , Bulent and Janczuk، نويسنده , , Adam J. and Wang، نويسنده , , Peng George، نويسنده ,
Abstract :
O-Alkylation of N-hydroxy-N-nitroso-1-naphthalenamine ammonium salt (neocupferron) leads to two isomers, (1,4) naphthoquinone O-alkyl oxime oxime (A) and N-alkyloxy-N′-naphthyldiimide N′-oxide (B). Characterization was done by 1H, 13C NMR and X-ray analysis. These derivatives showed increased stability compared to their parent compound, neocupferron, in the ability to release nitric oxide (NO). Some of these O-alkyl derivatives can be novel photo-releasing NO compounds.
