Author/Authors :
Alvarez-Gutierrez، نويسنده , , Julia M and Nefzi، نويسنده , , Adel and Houghten، نويسنده , , Richard A، نويسنده ,
Abstract :
The solid phase synthesis of N-substituted succinimides is described. The strategy used is based on the intramolecular cyclization of a dipeptide containing aspartic acid in the second position promoted by diphenylphosphorylazide (DPPA) and triethylamine. Large numbers of succinimides can be prepared using different, commercially available building blocks.
