Title of article
Introduction of cyclic guanidines into cationic lipids for non-viral gene delivery
Author/Authors
Frederic، نويسنده , , Marc and Scherman، نويسنده , , Daniel and Byk، نويسنده , , Gerardo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
675
To page
679
Abstract
In order to study the impact of chemical modifications of lipopolyamines on their gene delivery properties, we have introduced cyclic guanidines into the polyamine moiety. These lipopolyamino-cycloguanidines can be easily obtained by reacting polyamines with 2-methylmercapto-2-imidazolinium iodide or 2-methylmercapto tetrahydropyrimidinium iodide. These lipopolyamino-cycloguanidines constitute a novel family of cationic lipids.
Keywords
gene delivery , polyamine , cyclic guanidine , Cationic lipid
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636205
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