Title of article :
Synthesis of a complete set of l-difluorophenylalanines, l-(F2)Phe, as molecular explorers for the CH/π interaction between peptide ligand and receptor
Author/Authors :
Fujita، نويسنده , , Tsugumi and Nose، نويسنده , , Takeru and Matsushima، نويسنده , , Ayami and Okada، نويسنده , , Kazushi and Asai، نويسنده , , Daisuke and Yamauchi، نويسنده , , Yasuko and Shirasu، نويسنده , , Naoto and Honda، نويسنده , , Takeshi and Shigehiro، نويسنده , , Daiki and Shimohigashi، نويسنده , , Yasuyuki، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
A complete set of difluorophenylalanines in the l-configuration [l-(F2)Phe] (namely, l-(2,3-F2)Phe, l-(2,4-F2)Phe, l-(2,5-F2)Phe, l-(2,6-F2)Phe, l-(3,4-F2)Phe, l-(3,5-F2)Phe) was prepared and incorporated into the thrombin receptor-tethered ligand peptide SFLLRNP to identify the phenyl hydrogens of the Phe-2 residue involved in the CH/π receptor interaction.
Keywords :
Amino acid derivatives , Molecular recognition , Fluorine compounds , Polypeptides , Peptides , fluorine , amino acids
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
