Author/Authors :
Valliant، نويسنده , , John F and Schaffer، نويسنده , , Paul and Britten، نويسنده , , James F and Davison، نويسنده , , Alan and Jones، نويسنده , , Alun G and Yanch، نويسنده , , Jacquelyn C، نويسنده ,
Abstract :
Two corticosteroid–carborane esters were synthesized through the use of a BOP-Cl promoted esterification. The steroid–carborane conjugates are designed to selectively deliver boron to arthritic tissue for boron neutron capture synovectomy, a new therapeutic approach for rheumatoid arthritis.
Keywords :
boron neutron capture synovectomy , Carborane , Corticosteroids , arthritis , BOP-Cl
