Title of article
Lewis acid mediated cascade reactions of silyl-substituted methylenecyclopropyl ketones
Author/Authors
Peron، نويسنده , , Guillaume L.N and Kitteringham، نويسنده , , John and Kilburn، نويسنده , , Jeremy D، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
1615
To page
1618
Abstract
The Lewis acid mediated cyclisation of various silyl-substituted methylenecyclopropyl ketones has been investigated. The presence of the silyl-substituent enhances the reactivity of the methylene cyclopropane in comparison to our earlier study on non-silyl-substituted methylenecyclopropyl ketones, allowing milder Lewis acids (BF3·Et2O or BF3·2AcOH) to be used for the cyclisation reaction. The mild conditions used allow the allyl cation, formed as an intermediate in the cyclisation, to be trapped in further carbon–carbon bond-forming reactions.
Keywords
Cascade , Lewis acid , Cyclisation , Methylenecyclopropane
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636540
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