The synthesis of substituted pyridylpyrimidine fungicides using palladium-catalysed cross-coupling reactions

Various substituted phenyl, pyridyl and benzyl zinc chlorides have been generated from the corresponding lithium or magnesium organometallic reagents. These have been cross-coupled with 2-(6-bromo-2-pyridyl)pyrimidines in the presence of tetrakis(triphenylphosphine)palladium(0) to produce a series of substituted pyridylpyrimidine fungicides in 32–99% yields.