Title of article
Mechanism of action studies of cytotoxic marine alkaloids: ascididemin exhibits thiol-dependent oxidative DNA cleavage
Author/Authors
Matsumoto، نويسنده , , Sandra S and Sidford، نويسنده , , Mathew H and Holden، نويسنده , , Joseph A and Barrows، نويسنده , , Louis R and Copp *، نويسنده , , Brent R، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
1667
To page
1670
Abstract
The cytotoxic marine alkaloid ascididemin has been shown to be a thiol-dependent DNA cleaving agent. Previous mechanisms of action studies have concluded that DNA and/or the DNA processing enzyme topoisomerase II were the cellular targets for the alkaloid—this is the first direct evidence that a pyridoacridone alkaloid can cause DNA cleavage under physiological conditions.
Keywords
alkaloid , Marine metabolites , Cytotoxins
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636551
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