Title of article
A novel synthetic approach towards the AB-ring system of 9-azasteroids
Author/Authors
Stanetty، نويسنده , , Peter and Kremslehner، نويسنده , , Manfred and Mihovilovic، نويسنده , , Marko D، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
3
From page
1717
To page
1719
Abstract
Based on a high energy intermediate model for the inhibition of the ergosterol biosynthesis 9-azasteroids represent potential bioactive compounds as antimycotics. Herein, we describe a novel diastereoselective approach towards a substructure containing the AB-ring system bearing an angular methyl group. Utilizing Diels–Alder chemistry for the construction of the A-ring, the heterocyclic system (ring B) was constructed via a reductive cyclization methodology.
Keywords
Biologically active compounds , aza compounds , Diels–Alder reactions
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636562
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