Title of article
A versatile method for the preparation of 2,2-disubstituted morpholine analogues
Author/Authors
Takemoto، نويسنده , , Toshiyasu and Iio، نويسنده , , Yukiko and Nishi، نويسنده , , Takahide، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
1785
To page
1788
Abstract
We describe a versatile synthetic method for the preparation of 2,2-disubstituted morpholine analogues. Iodoetherification of 1,1-disubstituted olefin with N-Boc-aminoethanol using NIS proceeded smoothly in a regioselective manner and the following cyclization was accomplished in good yield. We successfully applied this method for the preparation of the key intermediate 2 of tachykinin receptor antagonist.
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636577
Link To Document