Author/Authors :
Hulme، نويسنده , , Christopher and Ma، نويسنده , , Liang and Romano، نويسنده , , Joseph J and Morton، نويسنده , , George S.F. Tang، نويسنده , , Sheng-Yuh and Cherrier، نويسنده , , Marie-Pierre and Choi، نويسنده , , Steve and Salvino، نويسنده , , Joseph and Labaudiniere، نويسنده , , Richard، نويسنده ,
Abstract :
This communication reveals novel applications of the CO2/MeOH reagent combination coupled with the UDC (Ugi/DeBOC/Cyclize) strategy. The Ugi five component condensation (5CC) affords carbamate protected amino-amides in good yield. When one of the supporting reagents employed in the Ugi reaction possesses a tethered amino-BOC protected functional group, subsequent acid treatment and proton scavenging results in rapid cyclization to cyclic ureas. Additionally, treatment of the 5CC product with base affords hydantoins in good yield, representing a novel and short approach to this class of molecule.
