Author/Authors :
Sharma، نويسنده , , G.V.M and Chander، نويسنده , , A.Subash and Goverdhan Reddy، نويسنده , , V and Krishnudu، نويسنده , , K and Ramana Rao، نويسنده , , M.H.V and Kunwar، نويسنده , , A.C، نويسنده ,
Abstract :
Stereoselective synthesis of chiral spiroacetals starting from enol-ester 1, derived from d-manno lactone, is described. The strategy involves 1,4-addition of a variety of alcohols to 1 in the presence of NBS to give α-bromo acetals, which undergo a regio- and stereoselective radical cyclisation to give highly functionalised chiral spiroacetals.
Keywords :
spiroacetals , Radical cyclisation , enol-ester , ?-bromo acetals
