Title of article
Synthesis of the Kopsia alkaloids (±)-11,12-demethoxylahadinine B, (±)-kopsidasine and (±)-kopsidasine-N-oxide
Author/Authors
Magnus، نويسنده , , Philip and Payne، نويسنده , , Andrew H. and Hobson، نويسنده , , Lindsay، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
2077
To page
2081
Abstract
The key intermediate homoannular diene 10 was converted into (±)-11,12-demethoxylahadinine 6 via the conjugate reduction and oxidation of 15 with Mn(dpm)2/PhSiH3/O2 at 0°C. Oxidation of 14 with PhI(OAc)2/MeOH followed by reduction gave 17, which was converted into (±)-kopsidasine 19 and kopsidasine-N-oxide 20. The structure of the latter was confirmed by comparison with an authentic sample, and by X-ray crystallography.
Keywords
kopsane , Alkaloids , lahadinine , ?-hydroxylation , kopsidasine , kopsidasine-N-oxide
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636643
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