Enantiomeric deoxy-l-nucleotides stabilize a Z-forming DNA decanucleotide

Two contiguous pairs of enantiomeric 2′-deoxy-l-ribonucleotides have been incorporated in a 5-methyl-CG alternating decadeoxyribonucleotide duplex. Data from circular dichroism and UV melting experiments indicate that the two base-pair long enantio-domain within the duplex was able to stabilize a Z-DNA-like conformation.