Author/Authors :
Shiomi، نويسنده , , Kazuro and Arai، نويسنده , , Noriko and Iwai، نويسنده , , Yuzuru and Turberg، نويسنده , , Andreas and K?lbl، نويسنده , , Heinz and ?mura، نويسنده , , Satoshi، نويسنده ,
Abstract :
A new chitinase inhibitor, named argifin, was isolated from the cultured broth of a fungal strain Gliocladium sp. FTD-0668. Argifin was a water-soluble cyclic pentapeptide, and its structure was elucidated as cyclo(Nω-(N-methylcarbamoyl)-l-arginyl-N-methyl-l-phenylalanyl-β-l-aspartyl-β-l-aspartyl-d-alanyl). The IC50 value of argifin against blowfly (Lucilia cuprina) chitinase was 3.7 μM.
Keywords :
enzyme inhibitor , fungi , natural product , Peptide
