Title of article
Structure of argifin, a new chitinase inhibitor produced by Gliocladium sp.
Author/Authors
Shiomi، نويسنده , , Kazuro and Arai، نويسنده , , Noriko and Iwai، نويسنده , , Yuzuru and Turberg، نويسنده , , Andreas and K?lbl، نويسنده , , Heinz and ?mura، نويسنده , , Satoshi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
3
From page
2141
To page
2143
Abstract
A new chitinase inhibitor, named argifin, was isolated from the cultured broth of a fungal strain Gliocladium sp. FTD-0668. Argifin was a water-soluble cyclic pentapeptide, and its structure was elucidated as cyclo(Nω-(N-methylcarbamoyl)-l-arginyl-N-methyl-l-phenylalanyl-β-l-aspartyl-β-l-aspartyl-d-alanyl). The IC50 value of argifin against blowfly (Lucilia cuprina) chitinase was 3.7 μM.
Keywords
enzyme inhibitor , fungi , natural product , Peptide
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636657
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