Title of article
Highly diastereoselective synthesis and template manipulation of the thiazolo[2,3-a]isoindolin-1-one ring system
Author/Authors
Allin، نويسنده , , Steven M and Vaidya، نويسنده , , Darshan G and Page، نويسنده , , Michael C. and Slawin، نويسنده , , Alexandra M.Z and Smith، نويسنده , , Tim، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
2219
To page
2222
Abstract
Condensation of 2-acetyl benzoic acid with l-cysteine esters proceeds with extremely high diastereoselectivity to produce the desired thiazolo[2,3-a]isoindolin-1-one products in good yield. The relative stereochemistry of the major diastereoisomer has been determined by X-ray crystallography. Stereoselective enolate alkylation of this substrate has been investigated as a method to manipulate the ring skeleton, and was found to proceed with up to exclusive levels of stereoselectivity.
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636688
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