Title of article
3-(N,N-Diacylamino)quinazolin-4(3H)-ones as enantioselective acylating agents for amines
Author/Authors
Al-Sehemi، نويسنده , , Abdullah G and Atkinson، نويسنده , , Robert S and Fawcett، نويسنده , , John and Russell، نويسنده , , David R، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
2239
To page
2242
Abstract
The presence of an N–N chiral axis in a 3-(N-benzoyl-N-isobutanoyl)aminoquinazolin-4(3H)-one (DAQ) bearing a chiral substituent in the 2-position of the quinazolinone allows separation of two enantiopure diastereoisomers; one of these diastereoisomers reacts with racemic 2-methylpiperidine to give (R)(+)-1-benzoyl-2-methylpiperidine (95% ee) and (S)-2-methylpiperidine (91% ee) even using stoichiometric quantities of reagents (1 equiv. DAQ: 2 equiv. amine).
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636699
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