Expedient synthesis of α,α-difluorohomopropargylic alcohols from TIPS-difluorobromopropyne via a Zn-mediated propargylation of aldehydes and ketones

The synthesis of α,α-difluorohomopropargyl alcohols containing an alkynyl silane moiety is reported. The title compound was prepared by the reaction of the organozinc derivative of TIPS-bromodifluoropropyne with aldehydes or ketones under mild conditions and in good yields.