Use of polymer supported thiophenol for the synthesis and purification of a benzimidazol-2-one library
Author/Authors :
Ermann، نويسنده , , Monika and Simkovsky، نويسنده , , Nadja M and Roberts، نويسنده , , Stanley M and Parry، نويسنده , , David M and Baxter، نويسنده , , Andy D and Montana، نويسنده , , John G، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Pages :
3
From page :
2483
To page :
2485
Abstract :
An efficient solution phase synthesis of substituted benzimidazol-2-ones is described. Polymer-supported thiophenol is used to remove excess alkylating agents. A library of 24 mono- and di-substituted benzimidazol-2-ones has been prepared in 60–99% yield and 65–99% purity.
