Enantioselective synthesis of the C14–C25 portion of the cytotoxic natural product, amphidinolide B1

The C14–C25 portion of the cytotoxic natural product, amphidinolide B1 (1), was synthesized enantioselectively using Myers asymmetric alkylation protocol, epoxide opening with higher order cuprate, Sharpless asymmetric epoxidation of allylic alcohol 17, and Sharpless asymmetric dihydroxylation of 24 as key steps.