Author/Authors :
Xia، نويسنده , , Jie and Piskorz، نويسنده , , Conrad F and Alderfer، نويسنده , , James L and Locke، نويسنده , , Robert D and Matta، نويسنده , , Khushi L، نويسنده ,
Abstract :
The total synthesis of a sialylated and sulfated oligosaccharide 1 representative of a structure occurring in respiratory mucins has been accomplished. Our strategy depends upon the employment of 2-naphthymethyl (NAP) protection for hydroxyl functions. Choice of the well-defined sialyl donor 15 was made because of its enhanced reactivity over the parent compound 14 for glycosylation.
