Title of article
Selective para metalation of unprotected 3-methoxy and 3,5-dimethoxy benzoic acids with n-butyl lithium–potassium tert-butoxide (LIC–KOR): synthesis of 3,5-dimethoxy-4-methyl benzoic acid
Author/Authors
Sinha، نويسنده , , Surajit and Mandal، نويسنده , , Bhubaneswar and Chandrasekaran، نويسنده , , Srinivasan، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
3157
To page
3160
Abstract
The potassium salt of 3-methoxy and 3,5-dimethoxy benzoic acids undergoes deprotonation at the position para to the carboxylate group selectively when treated with LIC–KOR in THF at −78°C and it has been extended to the synthesis of 3,5-dimethoxy-4-methyl benzoic acid.
Keywords
Metalation , Alkylation , carboxylic acids
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1637255
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