Title of article :
Solid phase synthesis of sulfahydantoins
Author/Authors :
Albericio، نويسنده , , Fernando and Garcia، نويسنده , , Javier and Michelotti *، نويسنده , , Enrique L and Nicolلs، نويسنده , , Ernesto and Tice *، نويسنده , , Colin M، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
A five step solid phase synthesis of 2-unsubstituted 1,2,5-thiadiazolidin-3-one 1,1-dioxides (sulfahydantoins) from Nα-FMOC-amino acids and aromatic aldehydes is described. The key step is the base mediated cyclitive cleavage of a resin bound Nα-(aminosulfonyl)-Nα-benzyl-amino acid to afford the desired product. This synthesis allows the preparation of a diverse library of compounds based on this heterocycle.
Keywords :
amino acids , Combinatorial chemistry , Libraries , thiadiazoles , cyclitive cleavage
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
