Title of article
Phosphonic derivatives of carbohydrates: chemoenzymatic synthesis
Author/Authors
Guanti، نويسنده , , Giuseppe and Banfi، نويسنده , , Luca and Zannetti، نويسنده , , Maria Teresa، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
3181
To page
3185
Abstract
A series of homologous racemic β-hydroxyaldehydes bearing a phosphonate group in the ω-position were synthesised and allowed to react with dihydroxyacetone phosphate (DHAP) via an enzymatic aldol addition catalysed by fructose 1,6-bisphosphate aldolase (FruA). After enzymatic dephosphorylation, a set of unnatural ω-phosphonic deoxysugars was obtained.
Keywords
enzyme reactions , aldol reactions , carbohydrate mimetics , phosphonic acids and derivatives
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1637271
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