Author/Authors :
Hِgberg، نويسنده , , Hans-Erik and Lindmark، نويسنده , , Marica and Isaksson، نويسنده , , Dan and Sjِdin، نويسنده , , Kristina and Franssen *، نويسنده , , Maurice C.R. and Jongejan، نويسنده , , Hugo and Wijnberg، نويسنده , , Joannes B.P.A. and de Groot، نويسنده , , Aede de Groot، نويسنده ,
Abstract :
Normally many lipases are efficient catalysts for the acetylation of alcohols with vinyl acetate. Unexpectedly, we found that some sterically hindered secondary alcohols react slowly to yield hemiacetal esters as mixtures of diastereomers. Their formation can be explained by the reaction of the alcohol with acetaldehyde that is produced by the lipase-catalysed splitting of vinyl acetate and subsequent acetylation of the resulting hemiacetal by the lipase.
