Title of article
Dysidotronic acid, a new and selective human phospholipase A2 inhibitor from the sponge Dysidea sp.
Author/Authors
Giannini، نويسنده , , Clelia and Debitus، نويسنده , , Cécile and Posadas، نويسنده , , Inmaculada and Pay?، نويسنده , , Miguel and D’Auria، نويسنده , , Maria Valeria، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
3257
To page
3260
Abstract
A new bioactive sesquiterpenoid, named dysidotronic acid 1, with a rearranged drimane skeleton has been isolated from the sponge Dysidea sp. from Vanuatu islands, along with bolinaquinone 2. The chemical structure of 1 was determined on the basis of spectroscopic data. Dysidotronic acid significantly inhibited human synovial phospholipase A2 (PLA2) at 10 μM, with an IC50 value of 2.6 μM and a higher selectivity and potency towards this enzyme than the reference inhibitor manoalide.
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1637314
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