Title of article
Facile synthesis and stabilization of 2-arachidonylglycerol via its 1,3-phenylboronate ester
Author/Authors
Herbert H. Seltzman، نويسنده , , Herbert H and Fleming، نويسنده , , Denise N and Hawkins، نويسنده , , Gregory D and Carroll، نويسنده , , F.Ivy، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
3589
To page
3592
Abstract
2-Arachidonylglycerol (2-Ara-Gl) was synthesized via the intermediacy of its 1,3-phenylboronic acid ester. The boronate ester is easily stable enough to enable chromatographic resolution from the corresponding 1-Ara-Gl boronate ester on normal phase elution yet immediately and completely hydrolyzes to 2-Ara-Gl and phenylboronic acid, without isomerization, by simple solution in aqueous-organic solvents. The phenylboronate ester of this 2-acylglycerol has the added advantage of being markedly more stable to both isomerization and oxidation upon storage than the labile 2-Ara-Gl.
Keywords
1 , 2-acylglycerols , 3-phenylboronate ester , stability
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1637510
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