Title of article
Highly regio- and stereospecific hydroxylation of C-1 position of 2-deacetoxytaxinine J derivative with DMDO
Author/Authors
Horiguchi، نويسنده , , Tohru and Cheng، نويسنده , , Qian and Oritani، نويسنده , , Takayuki، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
3907
To page
3910
Abstract
A simple chemical oxidation of 2-deacetoxytaxinine J derivative 3 using an excess of dimethyldioxirane (DMDO) results in a highly regio- and stereospecific hydroxylation of the C-1 position to afford the 1β-hydroxy α-4(20)-epoxide 6 and 1β-hydroxy β-4(20)-epoxide 7. A plausible mechanism of this reaction via ‘insertion’ is proposed.
Keywords
Taxoids , Dioxiranes , hydroxylation , regiospecificity , epoxides , stereospecificity , epoxidation
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1637667
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