Title of article :
Stereochemistry and total synthesis of janolusimide, a tripeptide marine toxin
Author/Authors :
Giordano، نويسنده , , Assunta and Della Monica، نويسنده , , Carmela and Landi، نويسنده , , Francesco and Spinella *، نويسنده , , Aldo and Sodano *، نويسنده , , Guido، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
The stereochemistry of janolusimide, a lipophilic tripeptide marine toxin, has been fully elucidated by stereoselective synthesis of the lactam component (5S)-3,3′-dimethyl-5-isopropylpyrrolidin-2,4-dione. The peptide was then synthesized in 13 steps and in 0.8% total yield.
Keywords :
Marine metabolites , molluscs , Imides , Peptides
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
