New synthesis of 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I (ABHxD-I), a potent metabotropic receptor agonist

A new versatile synthesis of racemic ABHxD-I, a potent mGluR agonist, is presented. The synthesis was achieved by means of a Wolff rearrangement, which converted a 3-diazobicyclo[2.2.1]heptan-2-one into a bicyclo[2.1.1]hexane derivative.