Title of article :
Synthesis of the novel antibacterial 6,8-dihydroxy-7-propyl-9H-pyrrolo[1,2-b][1,3]-benzoxazin-9-one
Author/Authors :
Huang، نويسنده , , Liren and Ellsworth، نويسنده , , Edmund L and Randhawa، نويسنده , , Sab and Stier، نويسنده , , Michael Yuan Ming Huang، نويسنده , , Yanting and Bird، نويسنده , , Paul and Lebedev، نويسنده , , Mikhail and Wu، نويسنده , , Kun and Micetich، نويسنده , , Ron G and Domagala، نويسنده , , John M and Singh، نويسنده , , Rajeshwar and Colbry، نويسنده , , Norm L، نويسنده ,
Abstract :
The total synthesis of 6,8-dihydroxy-7-propyl-9H-pyrrolo[1,2-b][1,3]benzoxazin-9-one, a novel antibacterial agent, is described. The key step in the synthesis is achieved via an oxidative cyclization of a phenol to the 2-position of a pyrrole using stoichiometric Pd(OAc)2. This provides a straightforward approach to the tricyclic structure of this prevously unreported template and future derivatives.
