Title of article :
Design and synthesis of a novel photoaffinity taxoid as a potential probe for the study of paclitaxel–microtubules interactions
Author/Authors :
Lin، نويسنده , , Songnian and Fang، نويسنده , , Kan and Hashimoto، نويسنده , , Masaru and Nakanishi، نويسنده , , Koji and Ojima، نويسنده , , Iwao، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
A novel and non-radioactive bifunctional photoaffinity probe (BPP) for the study of paclitaxel–microtubules interactions is designed and synthesized. This new BPP-taxoid bears a 3-nitro-5-trifluoromethyldiazirinyl-phenoxyacetyl group at C-3′N for photoaffinity/photocleavage and a biotin subunit at C-7 for affinity chromatography.
Keywords :
Taxoid , bifunctional probe , Diazirine , Biotin , photoaffinity label
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
