Title of article
Synthesis and biophysical studies of oligonucleotides containing hydroxamate linkages
Author/Authors
Ramasamy، نويسنده , , Kanda S and He، نويسنده , , Liyan and Stoisavljevic، نويسنده , , Vesna and Harpham، نويسنده , , Brent and Seifert، نويسنده , , Wilfried، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
4317
To page
4321
Abstract
Novel oligonucleotide dimers containing hydroxamate linkages (15 and 16) were synthesized, incorporated into oligonucleotide sequences and studied for their hybridization properties with complementary DNA and RNA targets. The modified oligonucleotides showed similar binding properties and enhanced resistance to exonucleases compared to natural oligonucleotides.
Keywords
oligonucleotides , Hydroxamate , backbone modification
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1637852
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