Author/Authors :
Hanashima، نويسنده , , Shinya and Mizushina، نويسنده , , Yoshiyuki and Yamazaki، نويسنده , , Takayuki and Ohta، نويسنده , , Keisuke and Takahashi، نويسنده , , Shunya and Koshino، نويسنده , , Hiroyuki and Sahara، نويسنده , , Hiroeki and Sakaguchi، نويسنده , , Kengo and Sugawara، نويسنده , , Fumio، نويسنده ,
Abstract :
Chiral sulfoquinovosyldiacylglycerols (SQDGs) have been synthesized to determine the absolute stereochemistry and the biological activities. The 1H NMR spectrum of a natural SQDG is comparable to that of synthetic (2S)-SQDG rather than that of the (2R) analogue. The biological activity of the respective isomers for DNA polymerase α and β inhibition was not distinguishable in the enzymatic assay.
