Title of article
Solid phase synthesis of glutamic acid derivatives via nucleophilic ring opening of N-Boc pyroglutamate with heteronucleophiles
Author/Authors
de Blas، نويسنده , , Jes?s and Dom??nguez، نويسنده , , Esteban and Ezquerra، نويسنده , , Jes?s، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
4567
To page
4571
Abstract
A solid phase method for the synthesis of glutamic acid derivatives based on the chemoselective ring opening of N-Boc pyroglutamic-Wang by heteronucleophiles is described. It allows the preparation of a large number of amides and esters of glutamic acid in a simple procedure with moderate to good yields and excellent purity.
Keywords
amino acids and derivatives , solid-phase synthesis
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1637957
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