Title of article :
Tritylisation of pyrene, perylene and coronene: a new family of switchable fluorescent labels
Author/Authors :
Shchepinov، نويسنده , , Mikhail S and Korshun، نويسنده , , Vladimir A and Egeland، نويسنده , , Ryan D and Southern، نويسنده , , Edwin M، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
The synthesis of novel fluorescent labels based on pyrene, perylene and coronene is described. Due to the trityl-type structure, their fluorescence may be reversibly switched on and off by changing the pH. This property can be used to expand the palette of fluorophores available for multicolour DNA detection on DNA chips. Some FRET and surface chemistry applications are also demonstrated.
Keywords :
Nucleic acids , Grignard reactions , Friedel–Crafts reactions , fluorescence , polycyclic aromatic compounds
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
