Title of article
A convenient and scaleable procedure for removing the Fmoc group in solution
Author/Authors
James E. Sheppeck II، نويسنده , , James E and Kar، نويسنده , , Heidi and Hong، نويسنده , , Hui، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
5329
To page
5333
Abstract
An improved and simple reagent system was developed to facilitate solution-phase deprotection of Fmoc-protected amines. Catalytic DBU in the presence of an aliphatic or polymer-supported thiol rapidly removed the Fmoc group to provide the amine free base in excellent yields and purity on multi-gram scale.
Keywords
protecting groups , Polymer support , thiols , supported reagents/reaction
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1638203
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