Highly efficient kinetic resolution of 2-cyclohexenyl acetate in Pd-catalyzed allylic alkylation

A new phosphine ligand has been synthesized and employed in the Pd-catalyzed alkylation of 2-cyclohexenyl esters. A very efficient resolution of 2-cyclohexenyl acetate was observed during alkylation. In addition, the reactivity and enantioselectivity showed a strong dependence on the acetate salt with the BSA/MOAc (M=alkali metal) base system during alkyation of cyclohexenyl carbonate.