A divergent protocol for solid-phase synthesis of highly substituted Bi-aryl furan derivatives

A versatile protocol for the solid-phase synthesis of highly substituted furan derivatives is discussed. This approach employs zincate 1 as the scaffold followed by sequential palladium-catalyzed cross-coupling reactions as the C–C bond-formation step. This methodology allows convenient modification of the furan core in three dimensions, giving rise to structurally diverse derivatives with overall good chemical purity and yield.