Enantiomerically pure dihydroimidazoisoquinolinones by reaction of isoquinoline with amino acid fluorides

Reaction of isoquinoline with N-tosylated (R)- or (S)-amino acid fluorides 2 or 5 gives access to novel optically active dihydroimidazoisoquinolinones 4 or 6, respectively, by N-acylation and attack of the deprotonated tosylamino group at position 1 of intermediate 2-tosylaminoacylisoquinolinium salts.