Author/Authors :
Madan، نويسنده , , Sachin and Arora، نويسنده , , Renu and Venugopalan، نويسنده , , P and Bari، نويسنده , , S.S، نويسنده ,
Abstract :
An effective route to novel C-3 substituted β-lactams is described. This involves reaction of a β-lactam carbocation equivalent with active aromatic nucleophiles in the presence of a Lewis acid. The stereospecificity of the formation of mono-substituted products may be rationalised on the basis of the SnCl4 mediated intermediate complex A that reacts via an SN2 mechanism.
