Author/Authors :
Nَbrega، نويسنده , , J.A. and Gonçalves، نويسنده , , Simone M.C. and Peppe، نويسنده , , C.، نويسنده ,
Abstract :
Bromocyanomethylation of a variety of carbonyl compounds to produce the corresponding 2-bromo-3-hydroxynitriles has been achieved in moderate to good yields by the action of dibromoacetonitrile and indium(I) bromide. Moderate diastereoselectivity was observed. Exclusive mono-coupling at the carbonyl group was found with 1,2-diketones and α-haloketones.
