Title of article :
Synthesis of a rhazinilam analogue acting as an inhibitor of tubulin assembly
Author/Authors :
Dupont، نويسنده , , Christophe and Guénard، نويسنده , , Daniel and Thal، نويسنده , , Claude and Thoret، نويسنده , , Sylviane and Guéritte، نويسنده , , Françoise، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
The synthesis of a di-nor-secorhazinilam analogue is described. This phenylpyrrole compound has been prepared by a Susuki cross-coupling reaction between 1,2,5 trisubstituted pyrrole halides and 2-N-(tert-butoxycarbonyl)aminophenyl boronic acid. In contrast to rhazinilam, this new phenylpyrrole inhibits the assembly of tubulin into microtubules.
Keywords :
phenylpyrroles , rhazinilam , biological activity tubulin , coupling reactions
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
