Radical cyclization of β-aminoacrylates: synthesis of bicyclic pyrrolidine derivatives

Radical cyclization of the β-aminoacrylate derived from 4-(2-bromoethyl)azetidin-2-one led to the stereoselective formation of a bicyclic β-lactam product, which may serve as a precursor for cis-2,5-disubstituted pyrrolidines.